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glp1 · metabolic

Semaglutide

Mechanistic stub

STUB — Semaglutide has not been written up yet. Machine-resolvable fields below are populated from PubChem and PubMed; every judgement (mechanism, claims, evidence appraisal) is still missing.

Sequence

No sequence has been verified against a primary source.

Honest appraisal

How good is the evidence

Mechanistic 1 human RCTs · 1 human trials · 0 animal

STUB — evidence has not been appraised. The counts below reflect only what PubMed labelled outright in the sampled records and are a floor, not a total.

Primary sources

The studies themselves

StudyDesignSubjectsQuality
Safety of Semaglutide
Smits MM, Van Raalte DH · Frontiers in endocrinology · 2021 PMID 34305810
narrative_review / mixed Mechanistic
risk of bias: unclear
Semaglutide for the treatment of obesity
Chao AM, Wadden TA · Trends in cardiovascular medicine · 2023 PMID 34942372
narrative_review / mixed Mechanistic
risk of bias: unclear
Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
Davies M, STEP 2 Study Group · Lancet (London, England) · 2021 PMID 33667417
rct / human Mechanistic
risk of bias: unclear
Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis
Tan HC, Marquez MM · Journal of the ASEAN Federation of Endocrine Societies · 2022 PMID 36578889
systematic_review / mixed Mechanistic
risk of bias: unclear
What we do not know
  • This entry is a stub: no claim, mechanism, or evidence appraisal has been written.
  • No dose from any cited study is recorded, because no full text has been read.
  • The amino-acid sequence has not been verified against a primary source.